Canadian Research Network for Adult Congenital Heart Disease Interventions
Research
CRN-ACHDi has clinical trials currently recruiting participants across Canada. These trials aim to advance our understanding of ACHDi and develop innovative treatments to improve patient outcomes. By participating in these studies, individuals contribute to cutting-edge research that has the potential to make a significant impact on the health and well-being of the ACHD community.
Trio-ASD
Comparative Effectiveness of Three Devices for Transcatheter Closure of Atrial Septal Defects for Adults: A Pilot Study (NCT04291898)
Principal Investigators: Dr. Eric Horlick, Dr. Lusine Abrahamyan, Dr. Jeff Healey
Co-Investigators: Dr. Marino Labinaz, Dr. Benjamin Hibbert, Dr. Dylan Taylor, Dr. Ronald Carere, Dr. Mounir Riahi, Dr. Anita Asgar, Dr. Reda Ibrahim, Dr. Josep Rodes Cabau, Dr. Guiseppe Martucci, Dr. George Tomlinson, Dr. Paul Dorian
Interventions: AMPLATZER™ Septal Occluder, Occlutech Figulla Flex II®, GORE® CARDIOFORM ASD Occluder
Study Design: To examine the comparative effectiveness of three commercially available devices (ASO, FSO, and GAO/GSO) for transcatheter closure of atrial septal defects (ASD) in adults using a pilot randomized controlled trial.
Participating Centres: Toronto General Hospital, Institut de Cardiologie de Montreal, Institut Universitaire de Cardiologie Et Pneumologie de Quebec/Hospital Laval, St. Paul's Hospital
Current Status: Recruiting
STOP
Medical Treatment With or Without Transcatheter Patent Foramen Ovale Closure for Older Patients With Cryptogenic Stroke and Patent Foramen Ovale (NCT05907694)
Principal Investigator: Dr. Josep Rodes-Cabau
Co-Investigators:
Intervention: Transcatheter PFO closure
Study Design: To determine the efficacy of PFO closure for the prevention of recurrent stroke in older patients with PFO and cryptogenic stroke using a randomized controlled trial.
Participating Centre: Institut Universitaire de Cardiologie Et Pneumologie de Quebec/University Laval
Current Status: Recruiting
CAPPRES
Canadian Patent Foramen Ovale and Perioperative Stroke Evaluation Study: A Feasibility Study (NCT05592301)
Principal Investigators: Dr. Eric Horlick, Dr. Lusine Abrahamyan, Dr. Aleksandra Pikula
Co-Investigators: Dr. Marcus Bernardini, Dr. George Djaiani, Dr. Ludwik Fedorko, Dr. Neil Fleshner, Dr. Jacobo Moreno Garijo, Dr. Danny Mandel, Dr. Carol-Anne Moulton, Dr. Ella Huszti, Dr. George Tomlinson, Dr. Christian Veillette, Dr. PJ Devereaux, Dr. Marko Mrkobrada, Dr. Eric Smith
Interventions: Diffusion-weighted Magnetic Resonance Imaging (DW-MRI), Transcranial Doppler (TCD), Transthoracic Echocardiogram (TTE)
Study Design: To determine if asymptomatic PFO is a risk factor for developing perioperative overt and covert stroke in patients undergoing non-cardiac surgery using a prospective cohort study.
Participating Centre: Toronto General Hospital, UHN
Current Status: Recruiting
HALTI
Discontinuation of Antithrombotic Treatment Following Patent Foramen Ovale Closure in Young Patients With Cryptogenic Stroke (NCT04475510)
Principal Investigator: Dr. Josep Rodes-Cabau
Co-Investigators:
Intervention: Antiplatelet treatment discontinuation
Study Design: To determine the safety of antithrombotic treatment discontinuation 12 months following successful transcatheter PFO closure.
Participating Centre: Institut Universitaire de Cardiologie Et Pneumologie de Quebec/University Laval
Current Status: Recruiting
C-ACHDiR
The Canadian Registry for Adults With Congenital Heart Disease Interventions (NCT04288596)
Principal Investigators: Dr. Eric Horlick, Dr. Lusine Abrahamyan
Intervention: Participants undergoing ACHD intervention
Study Design: To establish a rigorously developed registry to enable an impactful research agenda in adults with congenital heart disease interventions (ACHDi). The clinical and patient-reported information will enable the evaluation of care processes and outcomes in five most common ACHDi interventions by enabling prospective and retrospective registry-based studies to answer important clinical practice and policy-relevant questions.
Participating Centre: Toronto General Hospital
Current Status: Recruiting